Breast Cancer

Reduce the number of fractions. Excellent cosmesis.

Breast cancer is the leading cancer diagnosis in U.S. women and the second most common cancer in women worldwide.1 While survival rates continue to climb, the quality of life for women undergoing treatment and the impact both to their families and the economy cannot be underestimated.

While conventional radiation therapy is generally delivered to whole breast over the course of five to six weeks. MRIdian makes it possible to:

  • Reduced burden on the patient, with fewer treatments: therapy can be completed in 1 week vs. 4-6 weeks, with 1-10 fractions and the same cosmesis outcomes as conventional therapy2,3,4
  • Treat partial breast with very high doses in few sessions with excellent cosmesis2,3,4
  • Visualize the resection cavity during setup and for real-time tracking and beam gating, with high-contrast, high-resolution MR soft tissue imaging2,3,4
  • Greater clinical confidence in treating partial breast with very high doses in few sessions while achieving:
    • Excellent cosmesis2,3,4
    • Decreased PTV volumes with 0-1cm PTV margins — half what is typical with standard radiotherapy2,3,4
  • Provide patients an alternative to mastectomy2,3,4

Scroll down to learn more about MRIdian treatment for breast cancer.

 

 

1Ferlay, J., et al. (2018). Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Retrieved August 30, 2019 from https://gco.iarc.fr/today
2Kennedy, W. R., Thomas, M. A., Stanley, J. A., Luo, J., Ochoa, L. L., Clifton, K. K., et al. (2020). Single institution phase 1/2 prospective clinical trial of single-fraction, high-gradient adjuvant partial-breast irradiation for hormone-sensitive stage 0-I breast cancer. International Journal of Radiation Oncology * Biology * Physics. 107(2): 344-352. doi:10.1016/j.ijrobp.2020.02.021
3Zoberi, I. Physician Experience with MR Image-Guided RT for Breast Cancer. (2018) Industry Expert Theater Presentation at ASTRO 2018, San Francisco, CA. https://vimeo.com/300878157#t=980 Accessed Nov 19, 2020.
4Zoberi, I, Thomas, M.A., Curcuru, A., Green , O.L., Ochoa, L.L., Kashan, R. (2016). First-ever magnetic resonance image-guided radiation therapy for accelerated partial breast irradiation: early results of a single institution′s prospective experience. International Journal of Oncology * Biology * Physics. Poster Viewing Abstract 96(2)sppl: E47.

Important Safety Information

Indications for Use (IFU): The MRIdian Linac system, with magnetic resonance imaging capabilities, is intended to provide stereotactic radiosurgery and precision radiotherapy for lesions, tumors, and conditions anywhere in the body where radiation treatment is indicated. The MRIdian Linac System is not appropriate for all patients, including those who are not candidates for magnetic resonance imaging.

Important Safety Information (ISI): Radiation treatments may cause side effects that can vary depending on the part of the body being treated. The most frequent ones are typically temporary and may include, but are not limited to, irritation to the respiratory, digestive, urinary or reproductive systems; fatigue; nausea; skin irritation; and hair loss. In some patients, side effects can be severe. Treatment sessions may vary in complexity and duration.

Radiation treatment is not appropriate for all cancers. You should discuss the potential for side effects and their severity as well as the benefits of radiation and magnetic resonance imaging with your doctor to make sure radiation treatment is right for you.

Disclaimer: The opinions and clinical experiences presented herein are specific to the featured physicians and the featured patients and are for information purposes only. Nothing in this material is intended to provide specific medical advice or to take the place of written law or regulations. Results of treatment presented in the videos and information on this webpage are not indicative of typical or future results.

Discuss treatment options with your doctor, including the risks and benefits of the entire course of treatment specific to your individual needs. MRIdian Linac systems are only available at appropriately equipped facilities with specially trained physicians.

“ViewRay’s MRIdian is our first choice treatment for partial breast irradiation because we can actually see the treatment live and reduce certain errors that are known to happen with CT-based treatment. We’re no longer limited to the ‘peek and shoot’ mentality of other treatments.”

Phillip Beron, MD
UCLA
UCLA Clinical Experience with MRI-guided Adaptive Radiotherapy: Stereotactic Body Radiotherapy (SBRT)/Stereotactic Ablative Radiotherapy (SABR) for Abdominal Tumors and Accelerated Partial Breast Radiotherapy (APBR) for Breast CancerRadiosurgery Society
Webinar Held April 21, 2016

Noteworthy Clinical Findings

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis, MO recently completed a prospective phase I/II trial of 50 patients. It showed that single-fraction HG-PBI was well tolerated and resulted in few adverse events.

Study Specifics

Patients received postoperative single-fraction 20 Gy dose to the cavity surface while simultaneously prescribing 5 Gy to a PTV defined as the surgical bed plus a 1 cm margin

Key Findings

  • No grade 3-5 toxicities observed
  • 100% excellent to good cosmesis reported by both patients and treating physicians
  • Patient-reported quality of life did not decrease after treatment
  • Excellent early local, regional, and distant control rates

This study, Kennedy et al. (2020), was published in the February issue of the International Journal of Radiation Oncology * Biology * Physics.

Visible Benefits with MRIdian

MRIdian Bibliography

Scientific Presentations Related To Breast Cancer

Extreme Hypofractionated MRI-Guided Partial Breast Treatments, Clinical Outcomes on MRIdian

Imran Zoberi, MD
Siteman Cancer Center at Barnes Jewish Hospital and Washington University School of Medicine
ASTRO 2019

Dr. Zoberi has been compensated by ViewRay for his services in preparing and presenting this material for ViewRay’s further use and distribution.

Physician Experience with MR Image-Guided RT for Breast Cancer

Imran Zoberi, MD
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine
ASTRO 2018

Dr. Zoberi has been compensated by ViewRay for his services in preparing and presenting this material for ViewRay’s further use and distribution.

MR-IGRT for Accelerated Partial Breast Irradiation (APBI)

Maria Thomas, MD
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine – St. Louis, MO
ASTRO 2017

Dr. Thomas has been compensated by ViewRay for her services in preparing and presenting this material for ViewRay’s further use and distribution.

MR-Guided Breast Radiotherapy

Maria Thomas, MD, PhD
Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine – St. Louis, MO
Advanced Applications of MR-Guided Radiotherapy Symposium (Amsterdam, 2018)

Dr. Thomas has been compensated by ViewRay for her services in preparing and presenting this material for ViewRay’s further use and distribution.

Videos Related To Breast Cancer

ViewRay MRIdian for Prostate, Breast, and Pancreatic Cancer Treatment

October 22, 2019

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